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ACE-031 Peptide

Buy ACE-031 Peptide Georgia Online From Direct Sarms

ACE-031 is a synthetic protein developed to increase muscle mass and strength by inhibiting myostatin, a regulatory protein that limits muscle growth.

What is ACE-031?

ACE-031 is a synthetic protein designed to block myostatin, a natural protein that limits muscle growth. By inhibiting myostatin, ACE-031 aims to increase muscle mass and strength, making it a possible treatment for muscle-wasting conditions like muscular dystrophy.

It is a fusion protein that combines the activin receptor type IIB with a modified immunoglobulin domain to effectively neutralize myostatin. While early trials showed promising results in boosting muscle volume, its development has faced safety and regulatory challenges. More research is needed to better understand its potential uses and long-term effects.

How Does ACE-031 Work?

Ace-031 is a recombinant fusion protein that functions by inhibiting myostatin signalling. Myostatin is a regulatory protein that plays a key role in limiting muscle growth. The peptide functions by acting as a decoy receptor, binding to myostatin and other related proteins, preventing them from interacting with their natural receptor, activin receptor type IIB (ActRIIB).

This inhibition allows for an increase in muscle mass and strength by reducing the natural constraints on muscle growth. The mechanism has potential applications in treating muscle-wasting diseases, as it targets the physiological pathways that regulate muscle size and function.

What are the suggested research benefits of ACE-031 Peptide?

  • Promote Muscle Growth: It is a soluble form of activin receptor type IIB designed to enhance muscle development by inhibiting the activity of myostatin, a natural regulatory protein that limits muscle growth. By blocking myostatin, the compound allows for greater muscle mass accumulation, making it a potential therapeutic option for conditions associated with muscle loss or weakness, such as muscular dystrophy [1].
  • Enhances Muscle Strength: It has been studied for its potential to enhance muscle function by blocking myostatin and improving oxidative respiration. Research suggests it may increase muscle strength, boosting maximum force by 50% and total contractile force by 25%, without altering energy dynamics or ATP levels [2].
  • Potential Treatment For Muscle Wasting: Georgia Scientific research suggests it may offer promising benefits in managing muscle-wasting disorders, including conditions like Duchenne Muscular Dystrophy (DMD) and Sarcopenia [3]. By supporting muscle strength and reducing degeneration, this treatment could improve mobility and quality of life for those affected [4].
  • Muscle Tissue Repair: Georgia Studies suggest it can increase muscle mass and strength by promoting the growth and repair of muscle cells. This process helps to recover damaged tissues after intense physical activity, supporting faster healing and improved performance over time [5].
  • Reduces Fat Mass: Preclinical trials have shown that it has the ability to significantly reduce fat mass while simultaneously increasing lean body mass. This dual effect is particularly promising for individuals seeking to improve body composition, as it not only helps lower excess fat but also supports the development of stronger, healthier muscle tissue [5].
  • Improved Bone Density: Research also highlights its ability to increase bone mineral density, strengthening the skeletal system and reducing the risk of fractures. This benefit is particularly valuable for patients with muscle and bone conditions such as osteoporosis, providing them with greater support and resilience over time [6]. One study demonstrated the femur, a bone particularly prone to weakening in older adults, experienced a remarkable 132% increase in bone density, while vertebral bone density improved by 27%. These findings strongly suggest that ACE 031 interacts with a molecule beyond myostatin [7].
  • Reduces Fatigue: It has the potential to alleviate fatigue by improving muscle strength and endurance. By inhibiting myostatin and promoting muscle growth, it enhances overall muscle function, which may help reduce the physical fatigue associated with muscle-wasting disorders and improve quality of life for affected individuals [8].
  • Speeds Up Recovery Time: It may contribute to faster recovery times by enhancing muscle repair and regeneration. By promoting muscle growth and improving strength, it aids in the restoration of muscle tissue following injury or physical strain. This feature is particularly beneficial for individuals with conditions that impair muscle healing or for athletes seeking quicker recovery after intense physical activity [8].
  • Muscle Atrophy Due To Cancer: It’s anti-cancer effects go beyond muscle strength and composition. By preventing severe muscle atrophy (muscle loss), it helps extend lifespan during cancer treatment. Additionally, myostatin inactivation improves insulin sensitivity, reduces fat buildup, lowers inflammation, and improves bone metabolism, aiding fracture repair in cancer patients [9].

What ACE-031 products are available?

Buy ACE-031 Peptide Vial

Buy ACE-031 Peptide Vial 1 mg

Buy ACE-031 Peptide Georgia 1 mg vial for clinical research use from Direct Sarms. It contains a lyophilized powder which must be reconstituted with bacteriostatic water prior to use. 

Buy ACE-031 Pre-Mixed Pen

Buy ACE-031 Pre mixed Peptide

Buy ACE-031 Peptide Georgia 1 mg Pre-Mixed Pen for research use from Direct Sarms. Available as individual pre-filled cartridges or as a kit which includes a cartridge pen, carry case and pen needle tips.

Frequently Asked Questions (FAQ’s) about ACE-031 Peptide

Buy ACE-031 Peptide
Diagram of the muscular system

What is Myostatin?

Myostatin is a protein that plays a crucial role in regulating muscle growth. It is part of the transforming growth factor-beta (TGF-β) superfamily and is primarily produced in skeletal muscle cells. Myostatin acts as a limiting factor for muscle development by inhibiting the differentiation and proliferation of muscle cells. High levels of myostatin reduce muscle mass, while its suppression boosts muscle growth. This makes it a key focus in research on muscle-wasting diseases, athletic performance, and livestock breeding.

What are the differences between ACE-031 and Follistatin 344?

ACE-031 and Follistatin 344 are both inhibitors of myostatin, a protein that regulates muscle mass, but they work differently. ACE-031 is a synthetic protein that blocks myostatin by mimicking its receptor, while Follistatin 344 is a natural glycoprotein that inhibits myostatin and other TGF-beta proteins, potentially offering broader effects on muscle growth. Both are being studied for therapeutic uses, with differences in efficacy and safety.

What are the reported side effects of ACE-031?

Some reported adverse events in trials include nosebleeds, headaches, and reactions at injection sites, amongst other potential risks, highlighting the need for further research.

Can you buy ACE-031 legally?

Use of these products is not approved for human consumption or use and is currently only available for research purposes under controlled conditions. It has not yet been approved by regulatory bodies like the United States Food and Drugs Administration (FDA).

Further Reading

For more information, explore our latest blog posts dedicated to ACE-031 peptides.

Buy ACE-031 Peptide 1 mg High Purity Today!

Buy ACE-031 peptide from Direct Sarms, a trusted supplier for research-grade peptides. Available in multiple forms, including vials of lyophilized powder, 15 ml and 30 ml nasal sprays, and pre-mixed pens. Designed for laboratory use, ACE-031 offers high purity and quality to support consistent and accurate research results.

We ship these peptides with strict quality control to ensure they stay effective and reliable. Choosing Direct Sarms means you get accurate dosing and trustworthy results for your research.


Scientific References

[1] Kenneth M Attie, Niels G Borgstein, Yijun Yang, Carolyn H Condon, et al (2013) A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers – Muscle Nerve, 2013 Mar, Volume 47 (Issue 3), Pages 416-23.

[2] Hiroyasu Muramatsu, Taichi Kuramochi, Hitoshi Katada, Atsunori Ueyama, et al (2021) Novel myostatin-specific antibody enhances muscle strength in muscle disease models – Scientific Reports , 25 January 2021, Volume 11, Article number: 2160.

[3] Jong Hyeon Yoon and Ki-Sun Kwon (2021) Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics – Endocrinology and Metabolism, 2021, Volume 36 (Issue 3), Pages 478-490.

[4] Samuel M Cadena, Kathleen N Tomkinson, Travis E Monnell, Matthew S Spaits, et al (2010) Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type – Journal of Applied Physiology (1985), 2010 May 13, Volume 109 (Issue 3), Pages 635–642.

[5] Craig Campbell, Hugh J McMillan, Jean K Mah, Mark Tarnopolsky, Kathryn Selby, Ty McClure, et al (2016) Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial. Muscle Nerve, 2017 Apr, Volume 55 (Issue 4), Pages 458-464.

[6] Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, et al (2017) Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy – BMC Musculoskeletal Disorders, 2017 Jan 19, Volume 18, Page 20.

[7] P Bialek, J Parkington, X Li, D Gavin, et al (2014) A myostatin and activin decoy receptor enhances bone formation in mice – Bone, 2014 Mar, Volume 60, Pages 162-71.

[8] Nelly Béchir, Emilie Pecchi, Christophe Vilmen, Yann Le Fur, et al (2016) ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo – FASEB Journal, 2016 Oct, Volume 30 (Issue 10), Pages 3551-3562.

[9] H Q Han, Xiaolan Zhou, William E Mitch, and Alfred L Goldberg (2013) Myostatin/activin pathway antagonism: molecular basis and therapeutic potential – International Journal of Biochemistry & Cell Biology, 2013 Oct, Volume 45 (Issue 10), Pages 2333-47.


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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.